Abstract angiotensin ii the effector peptide of the renin angiotensin system regulates cellular growth in response to developmental physiological and pathological processesthe identification of renin angiotensin system components and angiotensin ii receptors in cardiac tissue suggests the existence of an autocrine paracrine system that has effects independent of angiotensin ii derived . Local renin angiotensin systems locally expressed renin angiotensin systems have been found in a number of tissues including the kidneys adrenal glands the heart vasculature and nervous system and have a variety of functions including local cardiovascular regulation in association or independently of the systemic renin angiotensin . The renin angiotensin aldosterone system raas plays an important role in regulating blood volume and systemic vascular resistance which together influence cardiac output and arterial pressureas the name implies there are three important components to this system 1 renin 2 angiotensin and 3 aldosterone. Recent studies are reviewed dealing with the putative roles of the cardiac renin angiotensin system in the development of pressure overload hypertrophy and the subsequent transition from adaptive hypertrophy to diastolic dysfunction impaired systolic function and cardiac failure the results of these studies which employed the aortic banded rat model of cardiac hypertrophy indicate that the . The local cardiac renin angiotensin aldosterone system second edition updates new findings on the local renin angiotensin systems ras with a focus on the local raass of the cardiovascular system and kidney edward d frohlich md macp facc is the alton ochsner distinguished scientist at the ochsner clinic foundation in new orleans louisiana
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